Abstract :Phage spray and kill bacteria, are natural occurring agents, ubiquitous in nature, and could
represent a global novel approach to therapy in both animals and humans. Nowadays, the problem
of antimicrobial resistance, rapidly increasing in recent years, represents a major public health
threat that particularly put interest in assessing the potential use of alternative antibacterial agents,
including bacteriophages. Phage therapy has many advantages over traditional antibiotics such
as specificity for the target organism, self-replicating activity, safety and the relative ease with
which naturally occurring phages can be isolated from the environment and propagated in large
numbers. The aim of this study was to evaluate the susceptibility of 12 Listeria monocytogenes (L.
monocytogenes) and 3 Campylobacter jejuni (C. jejuni) strains used for initial phage isolation to
bacteriophage activity and to some antibiotics frequently used in veterinary and human medicine.
Moreover, were port an interesting finding related to C. jejuni 12,662 strains and its apparent
reversion to sensitivity to antimicrobials (ciprofloxacin, nalidixic acid and tetracycline) after been
exposed to phage activity